Solicitations › DEPT OF DEFENSE › NAICS 541714

Virtual-Integrated Twin for Autonomous Lifesaving (VITAL)

DEPT OF DEFENSE · Solicitation DARPA-PS-26-26 · NAICS 541714 · Unrestricted (full and open) · Closed

Solicitation details

Solicitation number	DARPA-PS-26-26
Notice ID	3e66d960c0a14d51b236bbcf712d34cf
Agency	DEPT OF DEFENSE
Sub-tier	DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Contracting office	DEF ADVANCED RESEARCH PROJECTS AGCY
NAICS code	541714
Product / service code (PSC)	AC12
Set-aside	Unrestricted (full and open)
Notice type	Solicitation
Posted	21 April 2026
Response deadline	25 June 2026 (closed)

Description

UPDATE: The purpose of Amendment 1 to DARPA-PS-26-26, the Virtual-Integrated Twin for Autonomous Lifesaving (VITAL) Program Solicitation (PS), is to clarify the proposal abstract questions deadline and the 7-page proposal abstract section requirements. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative approaches to address challenges in developing continuously updating digital twin models of the cardiovascular system that combine patient data with biological physics to simulate in real time possible interventions and to predict their outcomes before actual intervention on a patient. The VITAL program will establish a foundation for causal, prediction-driven decision support in medicine, enabling clinicians and future autonomous systems to evaluate treatment options before they are applied. By defining when mechanistic digital twins, reduced-order models, and data-driven inference are reliable and actionable, VITAL will shift medical care from reactive assessment to anticipatory intervention. This capability has the potential to improve outcomes across acute, chronic, and emergent clinical settings.

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