Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO)

This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the Organizational Conflicts of Interest (OCI) Affirmations and Disclosure section. Updated questions, instructions, and content within the Research Security Disclosure section. Updated the instructions and intellectual property data assertions charts within the IP section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the Non-Commercial and Commercial tables were removed and replaced with the Background IP and Data Assertions table. Eliminated the Software Component Standards section. Updated the Human Subjects Research (HSR) table within the HSR section. Updated the Animal Subjects Research (ASR) table within the ASR section. Updated the questions and instructions within the Biosecurity section. 2) Cost Proposal Document (Word document) Updated the instructions within the Level of Effort and Labor Costs section. Added definitions for burdened labor rate and fully burdened labor rate to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000). Completed administrative update to a tab