High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Closed — responses were due 5 Nov 2026 · Unrestricted (full and open) · Defense Advanced Research Projects Agency (DARPA), DoD · NAICS 541714 · Solicitation DARPA-PA-27-01

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What happened next

This solicitation has closed — responses were due 05 November 2026.

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Solicitation details

Solicitation number	DARPA-PA-27-01
Notice ID	7cc49984be44476e8798ab0e0c1f253b
Agency	Department of Defense (DoD)
Sub-agency	Defense Advanced Research Projects Agency (DARPA)
Contracting office	DEF ADVANCED RESEARCH PROJECTS AGCY
NAICS code	541714 — Research and Development in Biotechnology (Except Nanobiotechnology)
Product / service code (PSC)	AC12
Set-aside	Unrestricted (full and open)
Notice type	Solicitation
Posted	28 October 2026
Response deadline	05 November 2026 (closed)
Competition	Competitive

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Description

UPDATE: The purpose of Amendment 1 to DARPA-PA-27-01, the HUBBLE Program Announcement (PA), is to update Attachment B and the verbiage in Section 4.1.2 and Section 7.8 of the Program Announcement. The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.

Version history

SAM.gov has posted 2 notices under solicitation DARPA-PA-27-01, oldest first.

08 October 2026 — Solicitation
28 October 2026 — Solicitation (this page)

Documents in the solicitation package

8 files are attached to this notice.

DARPA-PA-27-01-Amendment-01.pdf
Attachment_B_DARPA-PA-27-01__Model_OT_for_Research_HUBBLE_20261022.docx
DARPA-PA-27-01.pdf
Attachment_F_Risk_Matrix_HUBBLE.pptx
Attachment_E_Task_Description_Document_HUBBLE.docx
Attachment_D_Schedule_Milestone_and_Payments.xlsx
Attachment_C_Cost_Proposal_Spreadsheet_HUBBLE.xlsx
Attachment_A_Abstract_Template_and_Instructions__Phase_1_.docx

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Market context: DoD and NAICS 541714

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