Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability (CADENCC)

Agency: Department of the Army Office: Army Contracting Command, Edgewood Contracting Division Location: Fort Detrick, MD, USA Program Office: Capability Program Executive for Chemical, Biological, Radiological and Nuclear Defense (CPE CBRN Defense), Joint Project Lead Enabling Technologies (JPL ET) RPP Number: W911SR-26-R-CADENCC Date Issued: 03 September 2026 Proposals Due: 1500 hours, 17 September 2026 1. Through this Request for Project Proposal (RPP), the Capability Program Executive for Chemical, Biological, Radiological and Nuclear Defense s (CPE CBRN Defense) Joint Project Lead Enabling Technologies (JPL ET) seeks to develop Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability (CADENCC), an enabling capability that will accelerate clinical trial startup through implementation of Master Protocols, innovative technologies that support decentralized trial operations and augment data collection and analysis, and establishment of a pre-positioned clinical trial site network enabling CBRN defense readiness as described in the attached Statement of Objectives (SOO). The Government is hereby requesting formal submission of preproposals to execute a formal agreement under 10 USC 4022, Other Transaction Authority (OTA) for the prototype project described below. Upon receipt of a preproposal submitted in response to this RPP, the next steps are as follows: The Government will evaluate the preproposal. Discussions among the parties, whether verbally or in writing, will occur as appropriate. The Government may request a full proposal from the offeror. Additional discussions will occur as necessary. Award may be made after evaluation and selection of a successful submission. (Note: Awards are dependent upon the availability of funds.) 2. This RPP is issued to request project proposals in compliance with USC 4022 and is being issued for planning purposes only. It is not to be construed as a commitment by the Government to award an agreement, nor will the Government pay for the information solicited. 3. The JPL ET enables the rapid development, manufacture, and fielding of safe and effective medical solutions across the full product spectrum, including development, clinical trials, manufacturing, and validated biological threat detection materials. The objective of Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability (CADENCC) is to develop an enabling capability that will accelerate clinical trial startup through implementation of Master Protocols, innovative technologies that support decentralized trial operations and augment data collection and analysis, and establishment of a pre-positioned clinical trial site network enabling CBRN defense readiness. CADENCC will primarily conduct Phase I/Phase II clinical trials for pre-exposure prophylaxis (PrEP), post-exposure prophylaxis (PEP), and early treatment products which may be under Animal Rule. Any resultant award may be issued as a prototype Agreement under the authority of 10 USC 4022, with the expectation that quantities necessary for production, including fielding and testing new capabilities, may be non-competitively procured from awarded to the successful performer(s) of a prototype project in a follow-on production contract or other transaction agreement. 4. The Government will review/evaluate the submitted preproposals and if there is Government interest, the Agreements Officer may issue a request for full proposal (RFFP) in response to this RPP. The Government may award an agreement based on the submission or may require submission of additional details. The award of Prototype agreements shall be for the development of prototypes that are directly relevant to enhancing the mission effectiveness of personnel of the Department of Defense and the supporting platforms, systems, components, or materials proposed to be acquired or developed by the Department of Defense, or to improvement of platforms, systems, components, or materials in use by the Armed Forces. A prototype project can generally be described as a preliminary pilot, test, evaluation, demonstration, or agile development activity used to evaluate the technical or manufacturing feasibility or military utility of a particular technology, process, concept, end item, effect, or other discrete feature. Only a warranted Agreements Officer may obligate the U.S. Government to the expenditure of funds for awards under this Announcement. 5. Evaluation will be performed by CPE-CBRND personnel, other Federal Agency Representatives, or combinations thereof to enable the selection of the best preproposal submission, and/or subsequent full proposal submission. After evaluation and selection, an award will be made to the successful offeror(s). Subsequent awards depend upon the availability of funds and fulfillment of requirements and priorities determined to exist at the time of award. In some cases, funding priorities may change as certain scientific tasks are addressed and new mission assignments arise. Award may also be dependent upon demonstration by the offeror that they have adequately addressed the requirements. 6. The U.S. Government does not fund preparation of proposals or support work efforts or tasks that are inferred from discussions with technical project officers. The Offeror will not be reimbursed for any costs incurred prior to the effective date of the agreement. There are certain post-employment restrictions on former Federal officers and employees as defined in 18 USC 207 and FAR 3.104-3(d). If an offeror believes a post-employment restriction or conflict of interest exists, notification should be sent to the Agreements Officer prior to initiating efforts on a full proposal. 7. The Freedom of Information Act (FOIA) (5 USC 552) provides a statutory basis for public access to official U.S. Government records. Records are defined to include documentation received by the U.S. Government in connection with the transaction of public business. Certain types of information submitted to the Government in a process having the potential for award of an OT may be exempt from disclosure requirements of FOIA for a period of five (5) years from the date the Government receives the information. The types of information listed above may continue to be exempted, in whole or in part, from disclosure after the expiration of the five (5) year period if it falls within an exemption to the FOIA such as trade secrets and commercial or financial information obtained from a person that is privileged or confidential. It is the Offeror s responsibility to adequately mark any submitted information in accordance with the FOIA. 8. The Government is prohibited from soliciting and awarding actions to awardees that have engaged or are suspected to have engaged in criminal, fraudulent, or seriously improper conduct. 9. Prospective awardees shall complete electronic annual representations and certifications at https://sam.gov. By submission of an offer, the Offeror acknowledges the requirement that prospective awardees MUST be registered in the System for Award Management (SAM) database prior to award and through final payment of any contract resulting from this RPP. Offerors that are not registered should consider applying for registration immediately upon receipt of this solicitation. To remain registered in the SAM database after the initial registration, the Offeror is required to review and update, on an annual basis from the date of initial registration (or subsequent updates), its information in the SAM database to ensure it is current, accurate and complete. 10. Data submitted that cannot be disclosed to the public for any purpose, or used by the Government except for evaluation purposes, shall be marked appropriately on the title page and/or specific data sheets. 11. Questions regarding this announcement may be submitted by email to hunter.t.robinson4.civ@army.mil AND bianca.g.batista.civ@army.mil AND keith.d.pereira.civ@army.mil prior to 5 business days of the closing date. 12. The Government may award a follow-on production contract or Other Transaction (OT) for any OT awarded under this RPP if: (1) that participant in the OT, or a recognized successor in interest to the OT, successfully completed the entire prototype project provided for in the OT, as modified; and (2) the OT provides for the award of a follow-on production contract or OT to the participant, or a recognized successor in interest to the OT. 13. Proposals, Brochures, or other descriptions of general organizational or individual capabilities will not be accepted as a preproposal. An email will acknowledge receipt of a proposal. Generally, the Project Manager of the submitting organization should receive a decision letter or email upon completion of the evaluation and determination. 14. Administration: The Government will retain comments and information received in response…