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Proactive Health Office (PHO) Mission Office Innovative Solutions Opening (ISO)

Open — responses due 5 Mar 2029 (842 days left) · Unrestricted (full and open) · National Institutes of Health (NIH), HHS · NAICS 541715 · Solicitation ARPA-H-SOL-24-106

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A newer version of this notice has been posted. SAM.gov republished solicitation ARPA-H-SOL-24-106 on 10 June 2026. This page is kept because it is a real record, but the current requirement, dates and attachments are on the latest version. Read the latest version →

Solicitation details

Solicitation numberARPA-H-SOL-24-106
Notice IDf4c7cc9697ed46ff9487501fc3593122
AgencyDepartment of Health and Human Services (HHS)
Sub-agencyNational Institutes of Health (NIH)
Contracting officeADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
NAICS code541715 — Research and Development in the Physical, Engineering, and Life Sciences (Except Nanotechnology and Biotechnology)
Product / service code (PSC)AN13
Set-asideUnrestricted (full and open)
Notice typeSolicitation
Posted13 November 2025
Response deadline05 March 2029
CompetitionCompetitive

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Description

The Proactive Health Office (PHO) at ARPA-H is seeking solutions to improve the healthspan and health outcomes of Americans prior to the onset of disease and/or the development of diminished quality of life from illness. Specifically, PHO hypothesizes that 1) population-level improvements in access to and uptake of disease prevention and wellness-promoting behaviors and 2) development of novel early-detection methods and prophylactic interventions could drastically improve the health of American throughout their lives, and 3) that system level innovations are required for delivery of proactive health effectively. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the “Organizational Conflicts of Interest (OCI) Affirmations and Disclosure” section. Updated questions, instructions, and content within the “Research Security Disclosure” section. Updated the instructions and intellectual property data assertions charts within the “IP” section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the “Non-Commercial” and “Commercial” tables were removed and replaced with the “Background IP and Data Assertions” table. Eliminated the “Software Component Standards” section. Updated the Human Subjects Research (HSR) table within the “HSR” section. Updated the Animal Subjects Research (ASR) table within the “ASR” section. Updated the questions and instructions within the “Biosecurity” section. 2) Cost Proposal Document (Word document) Updated the instructions within the “Level of Effort and Labor Costs” section. Added definitions for “burdened labor rate” and “fully burdened labor rate” to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000). Completed administrative update to a tab

Version history

SAM.gov has posted 11 notices under solicitation ARPA-H-SOL-24-106, oldest first.

Documents in the solicitation package

3 files are attached to this notice.

  • Bundle of Attachments Amend 3.zip
  • PHO_MO_ISO_AMEND_3.pdf
  • Appendix A - ARPA-H Solutions Summary Template-Amend-3.docx

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Market context: HHS and NAICS 541715

About the buyer and the industry, not this specific solicitation. Source: USASpending.gov award data, updated nightly.

  • In fiscal year 2026, HHS obligated $406.8M across 212 contract actions under NAICS 541715.
  • 319 contracts worth $3.8B in this category end within the next 18 months.

HHS contracts under NAICS 541715 →

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