Solicitations › HEALTH AND HUMAN SERVICES, DEPARTMENT OF › NAICS 541715

Illumina DRAGEN Tier 3 Throughput License and v4 Server

HEALTH AND HUMAN SERVICES, DEPARTMENT OF · Solicitation 75N98026Q01167 · NAICS 541715 · No Set aside used · Responses due 14 September 2026

Solicitation details

Solicitation number	75N98026Q01167
Notice ID	6aea684c50ec4b30a97ec93f50bb2d70
Agency	HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier	NATIONAL INSTITUTES OF HEALTH
Contracting office	NATIONAL INSTITUTES OF HEALTH NLM
NAICS code	541715
Product / service code (PSC)	AJ12
Set-aside	No Set aside used
Notice type	Combined Synopsis/Solicitation
Posted	10 September 2026
Response deadline	14 September 2026
Place of performance	Bethesda, MD, USA

Description

The NHGRI Undiagnosed Diseases Program (UDP) requires both the Illumina DRAGEN 500,000Gb annual throughput license and the Illumina DRAGEN Server v4 to maintain secure, compliant, and high performance secondary analysis of next generation sequencing (NGS) data. DRAGEN serves as an essential computational supplement when UDP s sequencing workload exceeds CIT High Performance Computing Center allocations, enabling timely processing of whole genome, whole exome, and transcriptome datasets for patients with rare and unresolved diseases. The current DRAGEN server, procured in 2017, has reached end of support. Its CentOS 7 operating system lost vendor support and security updates on June 30, 2024, increasing operational risk. In addition, the legacy dual Intel Xeon processors, 512 Gb RAM, and first generation FPGA acceleration hardware cannot support updated DRAGEN pipelines, including pangenome references and improved germline/somatic variant calling workflows. These limitations reduce analytical accuracy, throughput, and system stability. To prevent analysis delays, maintain compliance with NIH IT security requirements, and sustain mission critical genomic interpretation capacity, the UDP must acquire both the updated throughput license and the next generation DRAGEN Server v4.

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