Solicitations › DEPT OF DEFENSE › NAICS 541714

Protein ENGineering (PENG)

DEPT OF DEFENSE · Solicitation DARPA-PS-26-129 · NAICS 541714 · Unrestricted (full and open) · Responses due 19 October 2026

Solicitation details

Solicitation number	DARPA-PS-26-129
Notice ID	8d7bb66b691a4def9e7efe4d4345bb7a
Agency	DEPT OF DEFENSE
Sub-tier	DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Contracting office	DEF ADVANCED RESEARCH PROJECTS AGCY
NAICS code	541714
Product / service code (PSC)	AC12
Set-aside	Unrestricted (full and open)
Notice type	Solicitation
Posted	21 August 2026
Response deadline	19 October 2026

Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

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