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Protein ENGineering (PENG)

Closed — responses were due 19 Oct 2026 · Unrestricted (full and open) · Defense Advanced Research Projects Agency (DARPA), DoD · NAICS 541714 · Solicitation DARPA-PS-26-129

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A newer version of this notice has been posted. SAM.gov republished solicitation DARPA-PS-26-129 on 21 August 2026. This page is kept because it is a real record, but the current requirement, dates and attachments are on the latest version. Read the latest version →

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This solicitation has closed — responses were due 19 October 2026.

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Solicitation details

Solicitation numberDARPA-PS-26-129
Notice IDbe313c6423e841ae9572a0878b3d9bbb
AgencyDepartment of Defense (DoD)
Sub-agencyDefense Advanced Research Projects Agency (DARPA)
Contracting officeDEF ADVANCED RESEARCH PROJECTS AGCY
NAICS code541714 — Research and Development in Biotechnology (Except Nanobiotechnology)
Product / service code (PSC)AC12
Set-asideUnrestricted (full and open)
Notice typeSolicitation
Posted07 August 2026
Response deadline19 October 2026 (closed)
CompetitionCompetitive

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Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

Version history

SAM.gov has posted 2 notices under solicitation DARPA-PS-26-129, oldest first.

Documents in the solicitation package

10 files are attached to this notice.

  • DARPA-PS-26-129.pdf
  • Attachment_I_Schedule_of_Milestones_and_Payments.xlsx
  • Attachment_E_Proposal_Instructions_and_Volume_II_Template_Cost.docx
  • Attachment_H_Task_Description_Document__TDD_.docx
  • Attachment_G_Model_Other_Transaction_for_Prototype.docx
  • Attachment_F_DARPA_Cost_Proposal_Spreadsheet.xlsx
  • Attachment_D_Proposal_Instructions_and_Volume_I_Template_Technical_and_Management.docx
  • Attachment_C_Proposal_Summary_Slide_Template.pptx
  • Attachment_B_Abstract_Instructions_and_Template.docx
  • Attachment_A_Abstract_Summary_Side.pptx

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Market context: DoD and NAICS 541714

About the buyer and the industry, not this specific solicitation. Source: USASpending.gov award data, updated nightly.

  • In fiscal year 2026, DoD obligated $96.9M across 47 contract actions under NAICS 541714.
  • 74 contracts worth $355.7M in this category end within the next 18 months.

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