Solicitations › HEALTH AND HUMAN SERVICES, DEPARTMENT OF

ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

Open — responses due 7 Oct 2026 (2 days left) · Unrestricted (full and open) · HEALTH AND HUMAN SERVICES, DEPARTMENT OF · NAICS 541714 · Solicitation ARPA-H-SOL-26-165

Solicitation details

Solicitation number	ARPA-H-SOL-26-165
Notice ID	8fad2e0c9f0b4559b939760a3f82ebbb
Agency	HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-agency	National Institutes of Health
Contracting office	ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
NAICS code	541714 — Research and Development in Biotechnology (Except Nanobiotechnology)
Product / service code (PSC)	AN13
Set-aside	Unrestricted (full and open)
Notice type	Solicitation
Posted	25 September 2026
Response deadline	07 October 2026

Description

The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth. ARPA-H anticipates multiple Other Transaction awards resulting from this announcement. Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165 Amendment 01 17 September 2026: This amendment includes updated hyperlinks and information on the updated Solutions summary portal. Questions and Answers 21 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation. All other questions are due by 23 September 2026 at 5:00PM ET. Amendment 02 23 September 2026: This amendment includes updates to Section 3, COSMOS Details; Section 4, Mandatory Experimental Design; as well as Correction to Figure 2. Questions and Answers 25 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation.

Version history

SAM.gov has posted 5 notices under solicitation ARPA-H-SOL-26-165, oldest first.

16 September 2026 — Solicitation
17 September 2026 — Solicitation
21 September 2026 — Solicitation
23 September 2026 — Solicitation
25 September 2026 — Solicitation (this page)

Documents in the solicitation package

10 files are attached to this notice.

ARPA-H-SOL-26-165_COSMOS_QA_Set_2_2026-09-25.pdf
ARPA-H-SOL-26-165_COSMOS_ISO_Amendment 02.pdf
ARPA-H-SOL-26-165_COSMOS_QA_Set_1_2026-09-21.pdf
Attachment E_COSMOS Administrative and National Policy Requirements.docx
ATTACHMENT A.1_Technical & Management Proposal Model (VOL I).docx
Attachment D_COSMOS Cost Proposal Template.xlsx
ATTACHMENT A.2_Task Description Document Model.docx
ATTACHMENT B_COSMOS Eligibility and Conformance Certification Sheet.docx
ATTACHMENT C COSMOS Schedule.xlsx
ATTACHMENT A.3_COSMOS Milestone and Payment Table.xlsx

Download them from SAM.gov, or open the solicitation in FedSift to read them with page-cited analysis.

Go deeper on this solicitation

FedSift reads the full solicitation package — every attachment — and pre-extracts the compliance matrix, evaluation factors, key risks, win themes and deal-breakers, each with a verbatim quote and the exact PDF page it came from. It scores the opportunity against your company profile, tells you whether to bid as prime or sub, and ranks teaming partners who could close your gaps.

Open the AI analysis in FedSift →

Free forever plan — no credit card. Browse solicitations without an account; sign in for AI analysis and matching.

Other open solicitations in NAICS 541714

precisionFDA cloud-based genomics platformHEALTH AND HUMAN SERVICES, DEPARTMENT OF · Due 09 October 2026
SURPASS Webinar and Proposers' Day InformationHEALTH AND HUMAN SERVICES, DEPARTMENT OF · Due 12 October 2026
UNifying Imaging with QUantum Entanglement (UNIQUE) Proposers' DayHEALTH AND HUMAN SERVICES, DEPARTMENT OF · Due 14 October 2026
Sepsis Research Blood Sample Collection ServicesDEPT OF DEFENSE · Due 15 October 2026
Request for Information (RFI) on Identifying Basic Research Challenges to Accelerate United States Biotechnology LeadershipENERGY, DEPARTMENT OF · Due 15 October 2026
Protein ENGineering (PENG)DEPT OF DEFENSE · Due 19 October 2026
Biobanking, Laboratory Analytics, and Associated Informatics Services for NIH BiorepositoriesHEALTH AND HUMAN SERVICES, DEPARTMENT OF · Due 20 October 2026
Biobanking, Laboratory Analytics, and Associated Informatics Services for NIH BiorepositoriesHEALTH AND HUMAN SERVICES, DEPARTMENT OF · Due 20 October 2026

All NAICS 541714 solicitations →

Source: this notice on SAM.gov. FedSift republishes public federal procurement data and is not affiliated with the U.S. Government. Always confirm dates and requirements against SAM.gov before responding.