Solicitations › Department of Health and Human Services › National Institutes of Health

ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

Open — responses due 7 Oct 2026 (2 days left) · Unrestricted (full and open) · National Institutes of Health (NIH), HHS · NAICS 541714 · Solicitation ARPA-H-SOL-26-165

Solicitation details

Solicitation number	ARPA-H-SOL-26-165
Notice ID	b92d3dc2c5c14c3aac3531c48ad79978
Agency	Department of Health and Human Services (HHS)
Sub-agency	National Institutes of Health (NIH)
Contracting office	ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
NAICS code	541714 — Research and Development in Biotechnology (Except Nanobiotechnology)
Product / service code (PSC)	AN13
Set-aside	Unrestricted (full and open)
Notice type	Solicitation
Posted	23 September 2026
Response deadline	07 October 2026

Description

The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth. ARPA-H anticipates multiple Other Transaction awards resulting from this announcement. Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165 Amendment 01 17 September 2026: This amendment includes updated hyperlinks and information on the updated Solutions summary portal. Questions and Answers 21 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation. All other questions are due by 23 September 2026 at 5:00PM ET. Amendment 02 23 September 2026: This amendment includes updates to Section 3, COSMOS Details; Section 4, Mandatory Experimental Design; as well as Correction to Figure 2.

Version history

SAM.gov has posted 5 notices under solicitation ARPA-H-SOL-26-165, oldest first.

16 September 2026 — Solicitation
17 September 2026 — Solicitation
21 September 2026 — Solicitation
23 September 2026 — Solicitation (this page)
25 September 2026 — Solicitation (latest)

Documents in the solicitation package

9 files are attached to this notice.

ARPA-H-SOL-26-165_COSMOS_ISO_Amendment 02.pdf
ARPA-H-SOL-26-165_COSMOS_QA_Set_1_2026-09-21.pdf
Attachment E_COSMOS Administrative and National Policy Requirements.docx
ATTACHMENT A.1_Technical & Management Proposal Model (VOL I).docx
Attachment D_COSMOS Cost Proposal Template.xlsx
ATTACHMENT A.2_Task Description Document Model.docx
ATTACHMENT B_COSMOS Eligibility and Conformance Certification Sheet.docx
ATTACHMENT C COSMOS Schedule.xlsx
ATTACHMENT A.3_COSMOS Milestone and Payment Table.xlsx

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Market context: HHS and NAICS 541714

About the buyer and the industry, not this specific solicitation. Source: USASpending.gov award data, updated nightly.

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297 contracts worth $2.4B in this category end within the next 18 months.

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